Tn 抗原模拟物的合理设计。
Rational design of a Tn antigen mimic.
机构信息
Departamento de Química, Universidad de La Rioja, Centro de Investigación en Síntesis Química, UA-CSIC, Madre de Dios, 51, 26006 Logroño, Spain.
出版信息
Chem Commun (Camb). 2011 May 14;47(18):5319-21. doi: 10.1039/c1cc10192g. Epub 2011 Mar 31.
PMID:21451866
Abstract
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
摘要
报道了一种新型 Tn 抗原模拟物，其中天然的基础氨基酸被非天然的α-甲基丝氨酸类似物取代。该衍生物对天然凝集素的亲和力与天然 Tn 相似，并保留了在含有 Tn 的糖肽与抗 MUC1 抗体相互作用中观察到的生物活性构象。
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