Advanced Laparoscopic Unit, University Hospital Virgen del Rocío, Betis-65, 1°, 41010, Seville, Spain.
Hernia. 2011 Aug;15(4):361-9. doi: 10.1007/s10029-011-0809-x. Epub 2011 Mar 31.
Our objective was to analyze the advantages and inconveniences associated with the use of fibrin sealant compared with mechanical means for mesh fixation following abdominal-wall surgery.
Literature search was conducted in MedLine, EMBASE, and Cochrane Library Plus databases. Articles were randomized clinical trials, nonrandomized comparative studies, and case series containing at least ten patients.
The fibrin sealant was shown to be biocompatible with the surrounding tissue. In patients treated with fibrin sealant, lower prevalence of acute and chronic postoperative pain was observed, and less hemorrhagic complications occurred. There are no data on the influence of fibrin sealant on seroma decrease. Efficiency in experimental models was similar to that observed for mechanical methods of fixation. Also, adhesions with fibrin sealant were less than that for mechanical methods.
Compared with mechanical methods, fibrin sealant is an efficacious alternative for mesh fixation postsurgery of the abdominal wall.
我们旨在分析与使用机械手段相比，在腹壁手术后使用纤维蛋白胶固定网片的优势和不便之处。
在 MedLine、EMBASE 和 Cochrane Library Plus 数据库中进行文献检索。文章为随机临床试验、非随机对照研究和至少包含 10 例患者的病例系列。
纤维蛋白胶与周围组织具有生物相容性。在使用纤维蛋白胶治疗的患者中，观察到急性和慢性术后疼痛的发生率较低，且出血性并发症较少。目前尚无关于纤维蛋白胶对减少血清肿影响的数据。在实验模型中的效率与机械固定方法相似。此外，纤维蛋白胶引起的粘连比机械方法少。
与机械方法相比，纤维蛋白胶是一种有效的腹壁手术后网片固定替代方法。
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