Prieto-Díaz-Chávez E, Medina-Chávez J Luis, Ramírez-Barba E J, Trujillo-Hernández B, Millán-Guerrero R O, Vásquez C
Departamento de Cirugía y Unidad de Investigación en Epidemiología Clínica Hospital General Zona y Medicina Familiar No. 1, Instituto Mexicano del Seguro Social, Colima, México.
Acta Chir Belg. 2008 Jul-Aug;108(4):433-7. doi: 10.1080/00015458.2008.11680256.
The purpose of our study was to evaluate the possibility of the reduction of peritoneal adhesions to a polypropylene mesh with fibrin glue.
Forty Wistar rats were assigned to two treatment groups: Group 1) hernioplasty with polypropylene mesh plus fibrin glue sealant, and Group 2) hernioplasty with polypropylene mesh without fibrin glue sealant. The variables evaluated were: presence and density of adhesion, organs or abdominal structures adhered to the polypropylene mesh, inflammatory tissular reaction and cell recount.
Group 1 presented a statistically lower adhesion percentage than Group 2 (40% versus 100%, P = 0.0003). The mean areas of mesh patch surfaces covered with adhesions were statistically different between Groups 1 and 2 (0.67 +/- 0.65 cm2 versus 1.60 +/- 0.51 cm2; P = 0.00001). Twelve rats presented with adhesions in Group 1; eleven were adhesions to the epiploon and one to the colon. In Group 2 there were 16 adhesions to the epiploon, 2 to the colon, 1 to the small intestine and 1 to the stomach. Tissular reaction comparison showed a significant difference (21 +/- 4.9 versus 17 +/- 4.1; P = 0.006).
Fibrin glue sealant significantly reduced the frequency and severity of intra-abdominal adhesions.
本研究的目的是评估用纤维蛋白胶减少聚丙烯网片与腹膜粘连的可能性。
将40只Wistar大鼠分为两个治疗组：第1组）聚丙烯网片疝修补术加纤维蛋白胶密封剂，第2组）聚丙烯网片疝修补术不加纤维蛋白胶密封剂。评估的变量包括：粘连的存在和密度、与聚丙烯网片粘连的器官或腹部结构、炎性组织反应和细胞计数。
第1组的粘连百分比在统计学上低于第2组（40%对100%，P = 0.0003）。第1组和第2组之间，粘连覆盖的网片表面平均面积在统计学上有差异（0.67±0.65 cm²对1.60±0.51 cm²；P = 0.00001）。第1组有12只大鼠出现粘连；11只与大网膜粘连，1只与结肠粘连。第2组有16只与大网膜粘连，2只与结肠粘连，1只与小肠粘连，1只与胃粘连。组织反应比较显示有显著差异（21±4.9对17±4.1；P = 0.006）。
纤维蛋白胶密封剂显著降低了腹腔内粘连的频率和严重程度。
Zotero 插件