Kitajima Mariko, Takayama Hiromitsu
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
Top Curr Chem. 2012;309:1-31. doi: 10.1007/128_2011_126.
Lycopodium alkaloids have attracted the attention of many natural product chemists and synthetic organic chemists due to their important biological activities and unique skeletal characteristics. In this review we describe isolation and asymmetric syntheses of several new alkaloids such as lycoposerramines-C, -V, -W, and cernuine, and show that asymmetric total synthesis played a key role in elucidating the structures of these complex natural products.
石松生物碱因其重要的生物活性和独特的骨架特征，吸引了众多天然产物化学家和有机合成化学家的关注。在本综述中，我们描述了几种新生物碱如石松胺-C、-V、-W和瑟诺因的分离及不对称合成，并表明不对称全合成在阐明这些复杂天然产物的结构中发挥了关键作用。
