Graduate School of Pharmaceutical Sciences, Chiba University , 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
J Am Chem Soc. 2014 Aug 20;136(33):11618-21. doi: 10.1021/ja507016g. Epub 2014 Aug 11.
The first asymmetric total synthesis of (+)-flabellidine (2) and the shortest total synthesis of (-)-lycodine (3) were accomplished by a strategy featuring the one-pot construction of a tetracyclic lycodine skeleton from a linear precursor, which was inspired by the biosynthetic consideration of Lycopodium alkaloids.
通过受石松生物碱生物合成考虑启发的策略，从线性前体一锅构建四环石松骨架，实现了 (+)-喇叭茶灵（2）的首次不对称全合成和 (-)-lycodine（3）的最短全合成。
