银屑病患者前瞻性队列中的关节炎发生率。
Incidence of arthritis in a prospective cohort of psoriasis patients.
机构信息
University of Toronto Psoriatic Arthritis Clinic, Centre for Prognosis Studies in the Rheumatic Diseases 1E-410B, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8.
出版信息
Arthritis Care Res (Hoboken). 2011 Apr;63(4):619-22. doi: 10.1002/acr.20401.
OBJECTIVE
Epidemiologic studies about the incidence of psoriatic arthritis (PsA) are limited to a few population-based studies. There are limited data regarding the incidence of PsA in patients with psoriasis. We aimed to determine the incidence of PsA among a prospective cohort of psoriasis patients.
METHODS
The setting is a prospective longitudinal cohort study of psoriasis patients without arthritis. The patients are assessed annually by a rheumatologist in order to detect the onset of arthritis. We summarize the results of 4 years of followup and report the cumulative incidence of PsA from the time of entry to the study that was estimated using an event per person-years analysis and a nonparametric analysis.
RESULTS
Three hundred thirteen psoriasis patients that had at least 1 year of followup were included in the analysis. The annual incidence rate was found to be 1.87 (95% confidence interval 0.71-3.03) PsA cases per 100 psoriasis patients.
CONCLUSION
The incidence rate of PsA in patients with psoriasis may be higher than previously reported, particularly among patients with moderate to severe psoriasis.
目的
关于银屑病关节炎（PsA）发病率的流行病学研究仅限于少数基于人群的研究。关于银屑病患者中 PsA 发病率的数据有限。我们旨在确定在银屑病患者的前瞻性队列中 PsA 的发病率。
方法
本研究为一项无关节炎的银屑病患者前瞻性纵向队列研究。每年由风湿病学家对患者进行评估，以发现关节炎的发生。我们总结了 4 年的随访结果，并使用事件/人年分析和非参数分析估计了从进入研究开始的 PsA 的累积发病率。
结果
纳入了 313 例至少随访 1 年的银屑病患者。发现每年的发病率为每 100 例银屑病患者中有 1.87（95%置信区间 0.71-3.03）例 PsA。
结论
银屑病患者的 PsA 发病率可能高于以往报告的发病率，尤其是中重度银屑病患者。
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