Challa Siva Reddy, Akula Annapurna, Metla Sushmitha, Gopal Pasumarthy N V
Department of Pharmacology, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India.
Indian J Exp Biol. 2011 Mar;49(3):207-10.
Reperfusion injury is remarkable clinical issue that needs to be resolved as ischemia-reperfusion is a common phenomenon encountered in numerous clinical situations. The present communication report the involvement of nitric oxide (NO) in cardioprotection offered by flavonoids (rutin and quercetin) against myocardial ischemia reperfusion. Rutin produced better cardioprotection than quercetin in normal and diabetic rats. The observed cardioprotection offered with quercetin and rutin was partially abolished by prior administration of nitric oxide synthase inhibitor, L-NAME (N-nitro-L-arginine methyl ester) in both normal and diabetic rats. L-NAME abolished the cardioprotective actions of rutin more strongly than the cardioprotective actions of quercetin. However, mechanistic study with NOS inhibitor implied the possible partial role of nitric oxide in infarct size limiting effect of quercetin and rutin
再灌注损伤是一个显著的临床问题，由于缺血-再灌注是在众多临床情况下都会遇到的常见现象，因此需要解决。本通讯报道了一氧化氮（NO）在黄酮类化合物（芦丁和槲皮素）对心肌缺血再灌注的心脏保护作用中的参与情况。在正常和糖尿病大鼠中，芦丁比槲皮素产生了更好的心脏保护作用。在正常和糖尿病大鼠中，预先给予一氧化氮合酶抑制剂L-NAME（N-硝基-L-精氨酸甲酯）可部分消除观察到的槲皮素和芦丁所提供的心脏保护作用。L-NAME对芦丁心脏保护作用的消除比槲皮素的心脏保护作用更强。然而，使用NOS抑制剂的机制研究表明，一氧化氮可能在槲皮素和芦丁的梗死面积限制作用中发挥部分作用
