Animal Sciences Group, Faculty of Agricultural Sciences, Lorestan University, Khoramabad, Iran.
Arch Anim Nutr. 2011 Feb;65(1):46-54. doi: 10.1080/1745039x.2010.533551.
The objective of this study was to investigate the effects of foetal undernutrition on the metabolism in growing lambs. Seven-month-old lambs whose mothers had been fed either restrictively (RN; n = 14) or adequately (AN; n = 6) in late gestation were fasted for three days. One hour before fasting and after 48 h and 72 h fasting, changes in plasma concentrations of metabolites, i.e. glucose, nonesterified fatty acids (NEFA), 3-beta-hydroxybutyrate (BOHB) and urea as well as hormones, i.e. insulin, the insulin-like growth factor (IGF-I) and leptin, were determined. Blood glucose, NEFA, urea, insulin, IGF-I and leptin were not different between the two groups of lambs. Unexpectedly, at the end of the 3 d fasting, in spite of lower NEFA concentration (1.6 +/- 0.03 vs. 1.9 +/- 0.05 mM in Groups RN and AN, respectively), the BOHB concentration in RN lambs (0.94 +/- 0.02 mM) was significantly higher than that in AN lambs (0.78 +/- 0.04 mM). This higher rate of BOHB production might be interpreted as perturbations in ketone body metabolism potentially induced by undernutrition during foetal life. However, more investigations are necessary to clarify this interrelationship.
本研究旨在探讨胎儿期营养不良对生长中羔羊代谢的影响。将 7 月龄、孕期后期分别接受限制（RN）或充足（AN）喂养的母羊所产羔羊禁食 3 天。禁食前 1 小时及禁食 48 小时和 72 小时后，检测血液代谢物（葡萄糖、非酯化脂肪酸、β-羟丁酸和尿素）和激素（胰岛素、胰岛素样生长因子 I、瘦素）的浓度变化。两组羔羊的血糖、非酯化脂肪酸、尿素、胰岛素、胰岛素样生长因子 I 和瘦素均无差异。但令人意外的是，尽管 RN 组羔羊的非酯化脂肪酸浓度较低（分别为 1.6 +/- 0.03 和 1.9 +/- 0.05 mM），但 3 天禁食结束时，其 β-羟丁酸浓度（0.94 +/- 0.02 mM）却显著高于 AN 组（0.78 +/- 0.04 mM）。这种较高的β-羟丁酸生成率可能是胎儿期营养不良潜在诱导的酮体代谢紊乱所致。然而，需要进一步研究以阐明这种相互关系。
