Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut 06269, United States.
Org Lett. 2011 May 6;13(9):2263-5. doi: 10.1021/ol2005775. Epub 2011 Mar 31.
A stereocontrolled approach to a key platensimycin intermediate was achieved from a commercially available furylcarboxylate. Key to our approach is the highly efficient formal [4 + 3] cyclocondensation of a substituted furan with tetrabromocyclopropene along with an intramolecular γ-alkylation to construct the final ring of the caged intermediate.
一种立体控制的方法被用于从商业可得的呋喃羧酸酯制备关键的盘菌霉素中间体。我们的方法的关键在于通过取代的呋喃与四溴环丙烯的高效的[4 + 3]环加成反应，以及分子内的γ-烷基化反应，构建了笼状中间体的最后一个环。
