Department of Civil and Environmental Engineering, Rice University, Houston, Texas 77005.
ACS Nano. 2009 Jul 28;3(7):1616-9. doi: 10.1021/nn9006835.
Manufactured nanomaterials (MNMs) are rapidly being incorporated into a wide variety of commercial products with significant potential for environmental release, which calls for eco-responsible design and disposal of nanoenabled products. Critical research needs to advance this urgent priority include (1) structure-activity relationships to predict functional stability and chemistry of MNMs in the environment and to discern properties that increase their bioavailability, bioaccumulation, and toxicity; (2) standardized protocols to assess MNM bioavailability, trophic transfer, and sublethal effects; and (3) validated multiphase fate and transport models that consider various release scenarios and predict the form and concentration of MNMs at the point of exposure. These efforts would greatly benefit from the development of robust analytical techniques to characterize and to track MNMs in the environment and to validate models and from shared reference MNM libraries.
人工合成纳米材料（MNMs）正在迅速被应用于各种商业产品中，具有显著的环境释放潜力，这就要求对纳米增强产品进行生态负责任的设计和处置。推进这一紧迫优先事项的关键研究需求包括：(1) 结构-活性关系，以预测 MNMs 在环境中的功能稳定性和化学性质，并辨别增加其生物利用度、生物积累和毒性的特性；(2) 用于评估 MNM 生物利用度、营养转移和亚致死效应的标准化协议；(3) 经过验证的多相命运和传输模型，该模型考虑了各种释放情景，并预测暴露点处 MNMs 的形态和浓度。这些努力将极大地受益于开发强大的分析技术，以对环境中的 MNMs 进行表征和跟踪，以及对模型进行验证，并受益于共享的参考 MNM 库。
