Gulati Neha, Gupta Himanshu
Babu Banarasi Das National Institute of Technology and Management, Lucknow, U.P, India.
Recent Pat Drug Deliv Formul. 2011 May;5(2):133-45. doi: 10.2174/187221111795471391.
The parenteral route of administration is the most effective route for the delivery of the active pharmaceutical substances with narrow therapeutic index, poor bioavailability especially for those drugs, prescribed to unconscious patients. To maintain a therapeutic effective concentration of the drug, it requires frequent injections which ultimately lead to patient discomfort. In parenteral drug delivery, major progress has been done in the field of formulation technologies so as to provide a targeted and sustained release of drug in predictable manner. The present article reviews recent patents and major advancements in parenteral drug delivery systems along with general introduction. This article also deals with importance of novel systems in drug delivery to overcome the problems associated with conventional parenteral drug delivery systems.
对于治疗指数窄、生物利用度差的活性药物成分，尤其是给无意识患者使用的那些药物，肠胃外给药途径是最有效的给药途径。为维持药物的治疗有效浓度，需要频繁注射，这最终会导致患者不适。在肠胃外给药方面，制剂技术领域已取得重大进展，以便以可预测的方式实现药物的靶向和持续释放。本文综述了肠胃外给药系统的近期专利和主要进展，并进行了概述。本文还探讨了新型给药系统在克服传统肠胃外给药系统相关问题方面的重要性。
