Khan Shadab, Sharma Ajay, Jain Vikas
Mahakal Institute of Pharmaceutical Studies, Ujjain, India.
Adv Pharm Bull. 2023 Jul;13(3):446-460. doi: 10.34172/apb.2023.056. Epub 2022 Sep 18.
Nanostructured Lipid Carriers (NLC) are nano-sized colloidal drug delivery system that contains a lipid mixture consisting of both solid and liquid lipids in their core. This Lipid-Based Nanosystem is introduced as a biocompatible, non-toxic, and safe nano-drug delivery system as compared to polymeric or metallic nanoparticles. Due to its safety, stability, and high drug loading capacity compared to other lipid-based nanocarriers, NLC gained the attention of researchers to formulate safe and effective drug carriers. The ability to increase drug solubility and permeability while encapsulating the drug in a lipidic shell makes them an ideal carrier for drug delivery through difficult-to-achieve routes. Surface modification of NLC and the use of various additives result in drug targeting and increased residence time. With such qualities, NLCs can be used to treat a variety of diseases such as cancer, infections, neurodegenerative diseases, hypertension, diabetes, and pain management. This review focuses on the recent developments being made to deliver the drugs and genes through different routes via these nanocarriers. Here, we also discuss about historical background, structure, types of NLC and commonly employed techniques for manufacturing lipid-based nanocarriers.
纳米结构脂质载体（NLC）是一种纳米级的胶体药物递送系统，其核心包含由固体和液体脂质组成的脂质混合物。与聚合物或金属纳米颗粒相比，这种基于脂质的纳米系统被介绍为一种生物相容性好、无毒且安全的纳米药物递送系统。由于与其他基于脂质的纳米载体相比，它具有安全性、稳定性和高载药量，NLC引起了研究人员的关注，以开发安全有效的药物载体。在将药物包裹在脂质外壳中的同时提高药物溶解度和渗透性的能力，使其成为通过难以实现的途径进行药物递送的理想载体。NLC的表面修饰和各种添加剂的使用导致药物靶向性和停留时间增加。凭借这些特性，NLC可用于治疗多种疾病，如癌症、感染、神经退行性疾病、高血压、糖尿病和疼痛管理。本综述重点关注通过这些纳米载体通过不同途径递送药物和基因的最新进展。在此，我们还讨论了NLC的历史背景、结构、类型以及制造基于脂质的纳米载体的常用技术。
