Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut - 250005, UP, India.
Curr Drug Deliv. 2011 Jul;8(4):373-80. doi: 10.2174/156720111795768022.
Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day's fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient compliance. Fast dissolving films consist of a very thin oral strip which dissolves in less than one minute when placed on the tongue. Dissolvable oral thin films are in the market since past few years in the form of breath strips and are widely accepted by consumers for delivering vitamins, vaccines and other drug products. The various manufacturing techniques for the preparation of films have also been detailed in the review. The present review details most of the patents on such fast dissolving films in recent years. A brief study has been made on various parameters which are used to evaluate such films. In case of chronic disorders these fast dissolving films are better for delivering drugs and obtaining faster therapeutic blood levels and superior in comparison to other oral conventional dosage forms.
速溶给药系统已被开发出来,作为一种替代传统剂型的口服药物输送方法,用于治疗慢性疾病。如今,速溶薄膜在掩盖苦味药物味道以提高患者顺应性方面,比传统片剂和胶囊更受欢迎。速溶薄膜由非常薄的口服条带组成,当放在舌头上时,在不到一分钟内溶解。可溶性口腔薄膜在过去几年中以口气条的形式在市场上销售,并被消费者广泛接受,用于输送维生素、疫苗和其他药物产品。该综述详细介绍了制备薄膜的各种制造技术。本文综述了近年来关于这种速溶薄膜的大部分专利。对用于评估这些薄膜的各种参数进行了简要研究。对于慢性疾病,这些速溶薄膜在输送药物方面效果更好,可以更快地达到治疗性血药浓度,优于其他口服常规剂型。