School of Social and Community Medicine, University of Bristol, Bristol, Oncology Centre, Addenbrooke's Hospital, Cambridge, and Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK.
BJU Int. 2011 Nov;108(9):1409-14. doi: 10.1111/j.1464-410X.2011.10174.x. Epub 2011 Mar 31.
• To assess whether a seasonal change in prostate specific antigen (PSA) levels can be detected in men recruited to a large clinical trial.
• A total of 66 969 men aged 50-69 years were drawn from a large study conducted at general practices across the UK between 2002 and 2007. • Trigonometric algorithms and regression methods were used to assess the relationship between the time of year and serum PSA and blood pressure measurements. • We obtained local daily mean temperatures and hours of sunlight per day to assess whether these factors were potential mechanisms for seasonal variation in PSA levels or blood pressure. • The proportion of participants who would be considered clinically at risk according to their PSA or blood pressure measurement, by month, was also assessed. • The strength of associations between time of year and blood pressure were used to reinforce conclusions from the PSA models.
• There was no relationship between time of year and PSA levels (P= 0.11) or between climate and PSA levels (P= 0.42). • No difference was found in the prevalence of clinically raised PSA content by month (P= 0.50). • This lack of an association with PSA content was despite our data being sufficient to provide clear evidence of an association between blood pressure and time of year (systolic P < 0.001; diastolic P < 0.001), and to show that this association was largely explained by climatic factors (temperature and sunlight).
• There was no pattern in PSA levels by time of year, air temperature or levels of sunlight in this cohort, so there is no need to take these factors into account when reviewing PSA results.
评估在参加大型临床试验的男性中是否可以检测到前列腺特异性抗原（PSA）水平的季节性变化。
共有 66969 名年龄在 50-69 岁的男性来自于 2002 年至 2007 年期间在英国的普通诊所进行的一项大型研究。使用三角算法和回归方法来评估一年中时间与血清 PSA 和血压测量值之间的关系。我们获得了当地的每日平均温度和每天的日照小时数，以评估这些因素是否是 PSA 水平或血压季节性变化的潜在机制。还评估了根据 PSA 或血压测量值，按月份计算处于临床风险的参与者的比例。
季节与 PSA 水平之间没有关系（P=0.11），季节与气候之间也没有关系（P=0.42）。按月份计算，临床上升高的 PSA 含量的患病率没有差异（P=0.50）。尽管我们的数据足以提供血压与季节之间存在关联的明确证据（收缩压 P<0.001；舒张压 P<0.001），并且表明这种关联主要是由气候因素（温度和阳光）解释的，但与 PSA 含量之间仍未发现关联。
在该队列中，PSA 水平、空气温度或阳光水平没有季节性模式，因此在审查 PSA 结果时无需考虑这些因素。
