Buist A, Norman T R, Dennerstein L
Key Centre for Women's Health in Society, Department of Community Medicine, University of Melbourne, Carlton, Vic., Australia.
J Affect Disord. 1990 Jul;19(3):197-206. doi: 10.1016/0165-0327(90)90092-m.
The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) have been shown to pass into breast milk following maternal ingestion. Generally, the doses to which children are exposed from breast milk, calculated from measured milk/plasma ratios, are small. Nevertheless most authors err on the side of caution and suggest that breastfeeding be avoided. There is inadequate research on the excretion of drugs into breast milk and the effects on the infant.
对于患有产后抑郁症或精神病的女性来说，是否继续母乳喂养是一个重要问题。本文对母乳中精神药物的文献进行了综述。所有主要类别的精神药物（抗抑郁药、抗精神病药、抗焦虑药、锂盐、催眠药）在母亲摄入后都已被证明会进入母乳。一般来说，根据测得的乳汁/血浆比率计算，婴儿从母乳中接触到的药物剂量很小。然而，大多数作者出于谨慎考虑，建议避免母乳喂养。关于药物排泄到母乳中以及对婴儿的影响，研究尚不充分。
