Geraci G, Arnone E, Lo Nigro C, Sciuto A, Modica G, Sciumè C
Universita degli Studi di Palermo, Italy.
G Chir. 2011 Mar;32(3):113-7.
Bleeding esophageal varices is the most serious complication of the portal hypertension, and the greater cause of dead (25% of the patients). The survival after esophageal varices bleeding depends in wide part from the swiftness and effectiveness of hemostasis and from the degree of functional liver reserve. Aim of our manuscript is to report our experience about hemostasis bleeding esophageal varices with endoscopic rubber band ligation.
From January 1999 to January 2008 we performed 302 esofagogastroduodenoscopy (EGDS) for esophageal varices bleeding (M: F ratio = 1.4:1, mean age 56.4 years, 62% of cases with HCV-related cirrhosis, 29% alcoholic cirrhosis and 9% cryptogenic cirrhosis; 20% suffered from chronic renal failure, 15% diabetes mellitus, 10% hepatocellular carcinoma on cirrhosis, 5% systemic encephalopathy and 1% AIDS). RESULTS; All patients were treated within 6 hours after the first reported episode of haematemesis and all received beta-blocker therapy after the episode. In the first phase of our experience were used rechargeable elastic ligator and then multibyte, even in combination with polidocanol sclerotherapy (8%) or injection of cyanoacrylate (5%). The best results were achieved with band ligation, in terms of primitive haemostasis, rebleeding, (3%), intraoperative mortality (1%) and 6 weeks mortality (1%).
To date, no single method applicable to all patients with bleeding esophageal varices, but endoscopic rubber band ligation is currently considered the first-line treatment of proper multidisciplinary approach to the patient, both during the acute event than prevention of rebleeding, because it is an effective, safe and repeatable, in experienced hands.
食管静脉曲张破裂出血是门静脉高压最严重的并发症,也是主要的死亡原因(占患者的25%)。食管静脉曲张破裂出血后的生存率在很大程度上取决于止血的迅速性和有效性以及肝脏功能储备程度。我们撰写本文的目的是报告我们使用内镜下橡皮圈套扎术治疗食管静脉曲张破裂出血的经验。
1999年1月至2008年1月,我们对302例食管静脉曲张破裂出血患者进行了食管胃十二指肠镜检查(EGDS)(男女比例为1.4:1,平均年龄56.4岁,62%的病例为丙型肝炎病毒相关性肝硬化,29%为酒精性肝硬化,9%为隐源性肝硬化;20%患有慢性肾衰竭,15%患有糖尿病,10%的肝硬化患者合并肝细胞癌,5%患有系统性脑病,1%患有艾滋病)。结果:所有患者在首次报告呕血发作后6小时内接受治疗,发作后均接受β受体阻滞剂治疗。在我们经验的第一阶段,使用了可充电弹性结扎器,然后是多字节的,甚至与聚多卡醇硬化疗法(8%)或氰基丙烯酸酯注射(5%)联合使用。就原发性止血、再出血(3%)、术中死亡率(1%)和6周死亡率(1%)而言,橡皮圈套扎术取得了最佳效果。
迄今为止,尚无适用于所有食管静脉曲张破裂出血患者的单一方法,但内镜下橡皮圈套扎术目前被认为是对患者进行适当多学科治疗的一线方法,无论是在急性事件期间还是预防再出血方面,因为在经验丰富的医生手中,它是一种有效、安全且可重复的方法。