Wolf Hanne Trap, Hegaard Hanne Kristine, Huusom Lene, Greisen Gorm, Hedegaard Morten
Medicinsk Afdeling, Nykøbing Falster Sygehus, 4800 Nykøbing Falster, Denmark.
Ugeskr Laeger. 2011 Mar 28;173(13):962-5.
Preterm birth increases the child's risk of cerebral palsy. Observational studies as well as randomized studies find that magnesium sulphate given to women in preterm birth decreases such risk. A Cochrane meta-analysis of the randomized studies shows no change in mortality, whereas some observational studies find a mortality decrease. It is important to identify the neuroprotective mechanism and to decide whether these results are relevant in the current Danish obstetrical practice. Should we use magnesium sulphate now or should questions about doses, time of administration and maternal side effects be answered first?
早产会增加儿童患脑瘫的风险。观察性研究以及随机研究均发现，给早产孕妇使用硫酸镁可降低此类风险。对随机研究的一项Cochrane荟萃分析显示死亡率没有变化，而一些观察性研究则发现死亡率有所下降。确定神经保护机制以及判断这些结果是否与当前丹麦的产科实践相关非常重要。我们现在就应该使用硫酸镁，还是应该先回答关于剂量、给药时间和母体副作用的问题呢？
