Herlin Troels, Sørensen Nini, Veirum Jens
Børneafdelingen, Århus Universitetshospital, Skejby, 8200 Århus N, Denmark.
Ugeskr Laeger. 2011 Mar 28;173(13):968-73.
Autoinflammatory diseases are characterized by attacks of apparently unprovoked inflammation without significant levels of autoantibodies or antigen-specific T-cells. Within the past decade, a number of different genetic causes of fever syndromes have been identified: familial Mediterranean fever (FMF), hyper IgD syndrome, cryopyrin-associated periodic syndromes and tumour necrosis factor receptor-associated periodic syndrome. The recent awareness and recognition of pathogenic mechanism of these diseases have led to new possibilities for medical treatment with targeted biological agents.
自身炎症性疾病的特征是出现明显无诱因的炎症发作，且自身抗体或抗原特异性T细胞水平不高。在过去十年中，已经确定了一些发热综合征的不同遗传病因：家族性地中海热（FMF）、高IgD综合征、冷吡啉相关周期性综合征和肿瘤坏死因子受体相关周期性综合征。最近对这些疾病致病机制的认识和了解为使用靶向生物制剂进行医学治疗带来了新的可能性。
