Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of Alberta, Edmonton, AB.
J Otolaryngol Head Neck Surg. 2011 Feb;40 Suppl 1:S65-9.
Human papillomavirus (HPV) is a well-established etiologic factor in oropharyngeal squamous cell carcinoma (OPSCC). The objective of this study was to evaluate the association between OPSCC and HPV-related cancerous lesions of the cervix.
Demographic, survival, and pathologic data on all female patients diagnosed with OPSCC in Alberta between 1998 and 2008 were collected. A review of pathology reports in these patients was undertaken to identify HPV-related cancerous lesions of the cervix. Standardized incidence ratios (SIRs) of cervical cancer in oropharyngeal cancer patients were calculated using control data obtained from provincial cancer surveillance. Overall and disease-specific survival of patients with OPSCC only versus patients with OPSCC and cervical cancer was calculated using Kaplan-Meier and Cox regression models.
Our results show a significantly elevated overall incidence of cervical cancer in women with OPSCC in comparison to the control population (SIR 29.4, 95% CI 12.05-74.98). Patients with OPSCC and cervical cancer also had a significantly improved disease-specific survival in comparison to patients with no history of cervical cancer.
Women with OPSCC have a significantly elevated risk of developing HPV-related genital cancers, which suggests frequent HPV coinfection of oropharyngeal and genital tissues in this patient population. Women with OPSCC with cervical cancer also have an improved disease-specific survival, as previously shown with HPV-associated OPSCC.
人乳头瘤病毒（HPV）是口咽鳞状细胞癌（OPSCC）的明确病因。本研究旨在评估 OPSCC 与宫颈 HPV 相关癌变之间的关联。
收集 1998 年至 2008 年期间在艾伯塔省诊断为 OPSCC 的所有女性患者的人口统计学、生存和病理数据。对这些患者的病理报告进行了审查，以确定宫颈 HPV 相关癌变。使用从省级癌症监测中获得的对照数据计算口咽癌患者宫颈癌的标准化发病比（SIR）。使用 Kaplan-Meier 和 Cox 回归模型计算仅患有 OPSCC 的患者与同时患有 OPSCC 和宫颈癌的患者的总生存率和疾病特异性生存率。
我们的结果表明，与对照人群相比，OPSCC 女性的宫颈癌总体发病率显著升高（SIR 29.4，95%CI 12.05-74.98）。与无宫颈癌病史的患者相比，患有 OPSCC 和宫颈癌的患者的疾病特异性生存率也显著提高。
患有 OPSCC 的女性发生 HPV 相关生殖道癌症的风险显著增加，这表明在该患者群体中，口咽和生殖道组织存在 HPV 合并感染。如前所述，患有宫颈癌的 OPSCC 女性的疾病特异性生存率也有所提高。
