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食物过敏治疗:治愈是否在望?

Food allergy therapy: is a cure within reach?

机构信息

Department of Pediatrics, Jaffe Food Allergy Institute, Mount Sinai School of Medicine, Box 1198, One Gustave L. Levy Place, New York, NY 10029, USA.

出版信息

Pediatr Clin North Am. 2011 Apr;58(2):511-30, xii. doi: 10.1016/j.pcl.2011.02.010.

Abstract

There is an unmet medical need for an effective food allergy therapy; thus, development of therapeutic interventions for food allergy is a top research priority. The food allergen-nonspecific therapies for food-induced anaphylaxis include monoclonal anti-IgE antibodies and Chinese herbs. The food allergen-specific therapies include oral, sublingual, and epicutaneous immunotherapy with native food allergens and mutated recombinant proteins. Diet containing heated milk and egg may represent an alternative approach to oral immunomodulation. Oral food immunotherapy remains an investigational treatment to be further studied before advancing into clinical practice.

摘要

目前,人们对有效治疗食物过敏的方法存在着未被满足的医学需求,因此,开发食物过敏的治疗方法是一个首要的研究重点。用于治疗食物诱发的过敏反应的非过敏原特异性疗法包括单克隆抗 IgE 抗体和中药。过敏原特异性疗法包括口服、舌下和经皮免疫疗法,使用天然食物过敏原和突变重组蛋白。含有加热牛奶和鸡蛋的饮食可能代表一种口服免疫调节的替代方法。口服食物免疫疗法仍然是一种研究性治疗方法,在进一步应用于临床实践之前,还需要进一步研究。

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