靶向IgE以促进食物过敏的口服免疫疗法：抗IgE疗法的潜在新作用？
Targeting IgE to facilitate oral immunotherapy for food allergy: a potential new role for anti-IgE therapy?
作者信息
Umetsu Dale T
机构信息
Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.
出版信息
Expert Rev Clin Immunol. 2014 Sep;10(9):1125-8. doi: 10.1586/1744666X.2014.948849.
PMID:25119422
Abstract
Food allergy is a major public health problem without satisfactory treatment options. Of several new treatments being studied, oral immunotherapy (OIT) appears to be the most promising. Unfortunately, OIT is associated with an unacceptably high frequency of allergic reactions. However, recent studies suggest that OIT might be made safer and faster when performed in conjunction with anti-IgE monoclonal antibody as an adjunctive treatment.
摘要
食物过敏是一个重大的公共卫生问题，目前尚无令人满意的治疗方案。在正在研究的几种新疗法中，口服免疫疗法（OIT）似乎最有前景。不幸的是，OIT与高得令人无法接受的过敏反应发生率相关。然而，最近的研究表明，当与抗IgE单克隆抗体联合作为辅助治疗进行时，OIT可能会更安全、起效更快。
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