Shimmyozu K, Kadokura N, Tara M, Maruyama I, Osame M
Third Department of Internal Medicine, School of Medicine, Kagoshima University.
Rinsho Ketsueki. 1990 Jun;31(6):860-1.
In order to elucidate the response of protein S (PS) and C4b-binding protein (C4bp) to danazol, we investigated the serial changes in plasma levels of PS and C4bp during danazol administration in 4 patients with endometriosis. Both total and free PS levels were significantly increased at the time of 2 to 3 weeks after danazol administration as compared to the pretreatment values, while C4bp levels were not changed at all. These results imply that danazol administration to PS deficiency would produce a significant increase in the basal level of free PS, suggesting a potential adjunct to anticoagulant treatment in PS deficiency.
为了阐明蛋白S（PS）和C4b结合蛋白（C4bp）对达那唑的反应，我们研究了4例子宫内膜异位症患者在服用达那唑期间血浆中PS和C4bp水平的系列变化。与治疗前的值相比，服用达那唑2至3周时，总PS水平和游离PS水平均显著升高，而C4bp水平则完全没有变化。这些结果表明，对PS缺乏症患者给予达那唑会使游离PS的基础水平显著升高，提示其可能成为PS缺乏症抗凝治疗的辅助手段。
