Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, London, UK.
Diabetes Care. 2011 May;34(5):1091-3. doi: 10.2337/dc10-2264. Epub 2011 Mar 31.
To investigate the association between first-trimester maternal serum levels of 25-hydroxyvitamin D (25-OH-D) as measured by liquid chromatography-tandem mass spectrometry and development of gestational diabetes mellitus (GDM).
We conducted a case-control study involving 248 women in the first-trimester of pregnancy, 90 of whom developed GDM and 158 remained normoglycemic.
Although booking 25-OH-D levels correlated negatively with 2-h glucose post-oral glucose tolerance test and positively with HDL cholesterol, as well as with ethnicity, obesity, and smoking (all P < 0.05), there were no statistically significant differences in baseline maternal mean 25-OH-D levels between those who subsequently developed GDM, 18.9 ng/mL (SD 10.7) and those who remained normoglycemic, 19.0 ng/mL (10.7) (P = 0.874), even after adjustment for possible confounders including sampling month (P = 0.784).
Our large and well-phenotyped prospective study did not find evidence of an association between first-trimester maternal levels of 25-OH-D and subsequent development of GDM.
通过液相色谱-串联质谱法检测妊娠早期母体血清 25-羟维生素 D（25-OH-D）水平，探讨其与妊娠糖尿病（GDM）发病的关系。
我们进行了一项病例对照研究，纳入了 248 名妊娠早期的妇女，其中 90 例发展为 GDM，158 例血糖正常。
尽管初诊时 25-OH-D 水平与口服葡萄糖耐量试验 2 小时后血糖和高密度脂蛋白胆固醇呈负相关，与种族、肥胖和吸烟呈正相关（均 P < 0.05），但在 GDM 组和血糖正常组之间，初诊时母体平均 25-OH-D 水平并无统计学差异，分别为 18.9ng/mL（SD 10.7）和 19.0ng/mL（SD 10.7）（P = 0.874），即使在校正了包括采样月份在内的可能混杂因素后（P = 0.784），结果仍如此。
我们的大型、表型良好的前瞻性研究并未发现妊娠早期母体 25-OH-D 水平与随后发生 GDM 之间存在关联。
