International Center for Oncologic Pathology Consultations, Centro Diagnostico Italiano, Milan, Italy.
Mod Pathol. 2011 Apr;24 Suppl 2:S53-7. doi: 10.1038/modpathol.2010.166.
In this essay, the role of the neural crest in the development of the vertebrate embryo is briefly described. The techniques used to document the neural crest origin of various cell types and the tumors arising from them are discussed, with emphasis on Le Douarin's quail-chick chimera model. The current dogma on the origin of the cells of the diffuse endocrine system is presented, and some personal conjectures based on the microscopic appearances of various types of normal, vestigial and neoplastic human tissues are offered to the reader as 'food for thought.'
本文简要描述了神经嵴在脊椎动物胚胎发育中的作用。讨论了用于记录各种细胞类型和源自它们的肿瘤的神经嵴起源的技术，重点介绍了 Le Douarin 的鹌鹑-鸡嵌合体模型。介绍了目前关于弥散内分泌系统细胞起源的主流观点，并向读者提供了一些基于各种类型正常、退化和肿瘤人类组织的微观外观的个人猜测，作为“思考的素材”。
