Laskowska-Klita Teresa, Chełchowska Magdalena, Blumska-Janiak Marta, Ambroszkiewicz Jadwiga, Łycka Renata, Gajewska Joanna, Leibschang Jerzy
Screening Test Department, Institute of Mother and Child, Warsaw.
Med Wieku Rozwoj. 2010 Oct-Dec;14(4):374-7.
Pro-hepcidin, mainly synthesized in hepatocytes is the pro-hormone of hepcidin which demonstrates antimicrobial activity and is the body's main regulator of iron homeostasis.
The estimation of serum pro-hepcidin concentrations in uncomplicated pregnancy and complicated by premature rupture of membranes (PROM) and in pregnancy induced hypertension (PIH).
The studies were performed in 24 women in pregnancy complicated by premature rupture of membranes, 31 women in pregnancy with induced hypertension and 35 healthy women in corresponding weeks of gestation (third trimester). Concentration of pro-hepcidin, C-reactive protein, white blood cell count, haemoglobin and haematocrit were studied using commercially available kits.
Levels of serum pro-hepcidin in studied pregnant women were similar and amounted respectively to 99.6 microg/L, 93.7 microg/L and 98.2 microg/L in PIH, PROM and in the uncomplicated pregnancy group. In the group of patients with PROM and PIH, concentration of haemoglobin was significantly lower than in healthy pregnant women, but remains in the physiological range. In the studied groups values of C-reactive protein and leucocytes count were normal. We did not observe any correlation between the concentration of serum pro-hepcidin and iron status measurements.
In pregnancies complicated by premature rupture of membranes and pregnancy induced hypertension with normal values of haemoglobin and haematocrit serum pro-hepcidin concentrations are similar to those observed in healthy pregnant women with normal course of pregnancy.
前铁调素主要在肝细胞中合成，是铁调素的前体激素，具有抗菌活性，是机体铁稳态的主要调节因子。
评估单纯妊娠、胎膜早破（PROM）合并妊娠及妊娠期高血压（PIH）患者血清前铁调素浓度。
对24例胎膜早破合并妊娠的妇女、31例妊娠期高血压妇女及35例相应孕周（孕晚期）的健康妇女进行研究。使用市售试剂盒检测前铁调素、C反应蛋白、白细胞计数、血红蛋白和血细胞比容的浓度。
研究的孕妇血清前铁调素水平相似，PIH组、PROM组和单纯妊娠组分别为99.6μg/L、93.7μg/L和98.2μg/L。PROM组和PIH组患者的血红蛋白浓度显著低于健康孕妇，但仍在生理范围内。研究组C反应蛋白和白细胞计数的值正常。我们未观察到血清前铁调素浓度与铁状态测量值之间存在任何相关性。
在胎膜早破合并妊娠及妊娠期高血压且血红蛋白和血细胞比容值正常的孕妇中，血清前铁调素浓度与正常妊娠的健康孕妇相似。
