Department of Chemistry, Fudan University, Shanghai, China.
Org Lett. 2011 May 20;13(10):2552-5. doi: 10.1021/ol200629y. Epub 2011 Apr 1.
A novel and unexpected reaction of 2-alkynylbenzaldoxime with aryne in the presence of silver triflate (10 mol %) under mild conditions is discovered. This reaction proceeds through 6-endo-cyclization, [3 + 2] cycloaddition, and rearrangement, leading to 2-oxa-6-aza-bicyclo[3.2.2]nona-6,8-diene derivatives in moderate to good yields.
在温和条件下，研究人员发现了 2-炔基苯甲肟与芳基在三氟甲磺酸银（10mol%）存在下的一种新颖且出人意料的反应。该反应通过 6-endo-环化、[3+2]环加成和重排进行，从而以中等至良好的收率得到 2-氧杂-6-氮杂双环[3.2.2]壬-6,8-二烯衍生物。
