单侧唇腭裂的单卵双生子和双卵双生子颅面特征的形态计量学分析。
Morphometric analysis of craniofacial features in mono- and dizygotic twins discordant for unilateral cleft lip and palate.
机构信息
Private practice, Ann Arbor, Michigan, USA.
出版信息
Angle Orthod. 2011 Sep;81(5):878-83. doi: 10.2319/121710-725.1. Epub 2011 Apr 1.
OBJECTIVE
To compare craniofacial differences between twins discordant for surgically repaired unilateral cleft lip and palate (CLP) during the developmental ages and to test the effect of zygosity on the shape and size of the craniofacial skeleton of the same twins by means of thin plate spline (TPS) analysis.
MATERIALS AND METHODS
Lateral and posteroanterior (PA) cephalometric films from 19 sets of monozygotic (MZ) twins (15 male and 4 female) and 10 dizygotic (DZ) twins (7 male and 3 female) were analyzed. TPS analysis evaluated statistically significant differences in the craniofacial shape and size between affected and unaffected twins within MZ and DZ twin couples.
RESULTS
No statistically significant differences in craniofacial shape or size between CLP and non-CLP MZ or DZ twins were observed. The level of morphological similarity in CLP vs non-CLP MZ twins was statistically greater than in DZ twins.
CONCLUSIONS
Morphometric analysis showed that surgically repaired CLP does not produce significant shape or size differences in the craniofacial features of MZ or DZ twins discordant for unilateral CLP.
目的
通过薄板样条（TPS）分析，比较单侧唇腭裂（CLP）手术修复后同卵双胞胎和异卵双胞胎之间颅面差异，并检验同卵双胞胎颅面骨骼形状和大小的同质性是否受双生子类型的影响。
材料和方法
对 19 对同卵（MZ）双胞胎（15 男 4 女）和 10 对异卵（DZ）双胞胎（7 男 3 女）的侧位和后前位（PA）头颅侧位片进行分析。TPS 分析评估了 MZ 和 DZ 双胞胎中受影响和未受影响的双胞胎之间颅面形状和大小的统计学显著差异。
结果
未观察到 CLP 和非 CLP MZ 或 DZ 双胞胎之间颅面形状或大小存在统计学差异。CLP 与非 CLP MZ 双胞胎的形态相似性程度明显高于 DZ 双胞胎。
结论
形态测量分析表明，单侧 CLP 手术修复不会导致 MZ 或 DZ 双胞胎之间颅面特征出现明显的形状或大小差异。
Zotero 插件