Gong Pingyuan, Zhang Fuchang, Ge Wanhu, Lei Xu, Chi Wanyu, Zhang Kejin, Zheng Anyun, Gao Xiaocai
Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi'an, China.
J Neurogenet. 2011 Mar;25(1-2):27-34. doi: 10.3109/01677063.2011.569804. Epub 2011 Apr 4.
The 5-hydroxytryptamine (5-HT) system is widely distributed in the central nervous system. A growing body of evidence has suggested that the neurotransmitter system is implicated in the functions of the prefrontal cortex. So far, several studies have revealed that some functional genetic variants in TPH2, 5-HT2A, and 5-HT6 genes are possibly related to executive function. To investigate the potential influences of TPH2, 5-HT2A, and 5-HT6 on the components of executive function, the authors performed a population-based study with standard cognitive paradigms in a young Chinese Han group. The results indicated that -703 G/T polymorphism of TPH2 was associated with the performance of response inhibition (p = .002) and the T allele carriers (TT and GT) had fewer errors than the noncarriers (GG) did in the response inhibition test. Furthermore, there were no significant associations of the T102C in 5-HT2A and T267C in 5-HT6 with the components of executive function after correcting for multiple tests (p > .05). The present study suggests that TPH2 contributes distinctively to the inhibition domain of executive function, whereas 5-HT2A and 5-HT6 show no striking effects on executive function in the Chinese Han population.
5-羟色胺（5-HT）系统广泛分布于中枢神经系统。越来越多的证据表明，该神经递质系统与前额叶皮质的功能有关。到目前为止，多项研究表明，TPH2、5-HT2A和5-HT6基因中的一些功能性遗传变异可能与执行功能有关。为了研究TPH2、5-HT2A和5-HT6对执行功能各成分的潜在影响，作者在中国汉族青年人群中采用标准认知范式进行了一项基于人群的研究。结果表明，TPH2的-703 G/T多态性与反应抑制表现相关（p = 0.002），在反应抑制测试中，T等位基因携带者（TT和GT）的错误比非携带者（GG）少。此外，在进行多重检验校正后，5-HT2A中的T102C和5-HT6中的T267C与执行功能各成分之间无显著关联（p > 0.05）。本研究表明，TPH2对执行功能的抑制领域有独特贡献，而5-HT2A和5-HT6在中国汉族人群中对执行功能无显著影响。
