Key Laboratory of Resource Biology and Biotechnology in Western China (Ministry of Education), College of Life Science, Institute of Population and Health, Xi'an, 710069, China.
J Mol Neurosci. 2012 Feb;46(2):352-61. doi: 10.1007/s12031-011-9592-5. Epub 2011 Jul 5.
Semantic and episodic memories were two different attributes of long-term memory. In the past few years, plenty of physiological evidence has indicated that neural plasticity is involved in the formation of long-term memory. In the present study, we hypothesized that some functional variants of neural plasticity-related genes were related to episodic and semantic memories. To confirm this hypothesis, we examined the relationship of 13 plasticity-related genes with episodic and semantic memories. The results indicated that there was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT ( 6 ) (χ (2) = 16.638, p = 0.0002). However, the functional variations in BDNF, COMT, DBH, DRD ( 2 ), DRD ( 3 ), DRD ( 4 ), MAOA, TPH ( 2 ), 5-HT ( 2A ), GRM ( 1 ), and GRIN2B had no observable effects on the memories. Our preliminary results confirm the hypothesis that a small number of functional variants of the neural plasticity-related genes, such as T267C in 5-HT ( 6 ), play important roles in human specific memory.
语义记忆和情景记忆是长时记忆的两个不同属性。在过去的几年中，大量的生理证据表明神经可塑性参与了长时记忆的形成。在本研究中，我们假设一些与神经可塑性相关的基因的功能变体与情景记忆和语义记忆有关。为了验证这一假设，我们研究了 13 个与可塑性相关的基因与情景记忆和语义记忆的关系。结果表明，5-HT（6）T267C 三个基因型组之间的语义记忆评分存在统计学差异（χ²=16.638，p=0.0002）。然而，BDNF、COMT、DBH、DRD（2）、DRD（3）、DRD（4）、MAOA、TPH（2）、5-HT（2A）、GRM（1）和 GRIN2B 中的功能变异对记忆没有明显影响。我们的初步结果证实了这样一个假设，即一小部分与神经可塑性相关的基因的功能变体，如 5-HT（6）中的 T267C，在人类特定记忆中起着重要作用。
