Shakhgil'dian I V, Farber N A, Kuzin S N, Cheshik S G, Drobeniuk Zh A, Mikhaĭlov M I, Khukhlovich P A, Gorbunov M A, Ikoev V N, Golosova T V
Vestn Akad Med Nauk SSSR. 1990(7):29-32.
The incidence of HBs- and HBe-antigens detection in future mothers was studied in Moscow, Uzbekistan, and Moldavia, and the incidence of hepatitis B (HB) virus transmission from mothers with persisting HBs-antigenemia to their offspring. In reverse passive hemagglutination test, HBsAg was detected in 1.1% of pregnancies in Moscow, in 6.3% of pregnancies in Uzbekistan, and in 5.4% of pregnancies in Moldavia. In these regions, immunofluorescence revealed HBe-antigen in HBsAg carriers in 5.2, 13.9, and 16.3%, respectively. Perinatal infection with HB virus was found in 26.1% of births to HBsAg carriers in Moscow and in 40% in Uzbekistan and Moldavia; in the latter two regions 16.0% and 13.3% of these births were found to become chronic carriers of HBsAg. In the presence of persistence of HBeAg in HSsAg carriers, from 89 to 100% births to these mothers showed the development of durable HBs-antigenemia, while in the presence of anti-HBe such outcome was noted in only 3%. Specific anti-HBs-immunoglobulin administered to infants born to HBsAg carriers exerted a protective effect by reducing the HB virus infection rate in the first 6 months of life, but failed to prevent completely the development of HB virus infection. The necessity of a wide-scale vaccination against HB in order to prevent HB virus infection of neonates is emphasized.
在莫斯科、乌兹别克斯坦和摩尔多瓦，对未来母亲中乙肝表面抗原（HBs）和乙肝e抗原（HBe）的检测率，以及乙肝（HB）病毒从持续存在HBs抗原血症的母亲传播给其后代的发生率进行了研究。在反向被动血凝试验中，莫斯科1.1%的孕妇、乌兹别克斯坦6.3%的孕妇和摩尔多瓦5.4%的孕妇检测出HBsAg。在这些地区，免疫荧光法显示，HBsAg携带者中HBe抗原的检出率分别为5.2%、13.9%和16.3%。在莫斯科，HBsAg携带者分娩的婴儿中26.1%发生围产期HB病毒感染，在乌兹别克斯坦和摩尔多瓦这一比例为40%；在后两个地区，这些分娩的婴儿中有16.0%和13.3%成为HBsAg慢性携带者。当HBsAg携带者持续存在HBeAg时，这些母亲分娩的婴儿中有89%至100%出现持久的HBs抗原血症，而当存在抗HBe时，只有3%出现这种结果。给HBsAg携带者所生婴儿注射特异性抗HBs免疫球蛋白，通过降低出生后头6个月的HB病毒感染率发挥了保护作用，但未能完全预防HB病毒感染的发生。强调了为预防新生儿HB病毒感染进行大规模乙肝疫苗接种的必要性。
