Department of Preventive Medicine, Keck School of Medicine of USC, 1540 Alcazar St, CHP-220, Los Angeles, CA 90089-9011, USA.
Genome Med. 2011 Mar 25;3(3):18. doi: 10.1186/gm232.
Despite years of investigation, very little is known about the genetic predisposition for gestational diabetes mellitus (GDM). However, the advent of genome-wide association and identification of loci contributing to susceptibility to type 2 diabetes mellitus has opened a small window into the genetics of GDM. More importantly, the study of the genetics of GDM has not only illuminated potential new biology underlying diabetes in pregnancy, but has also provided insights into fetal outcomes. Here, I review some of the insights into GDM and fetal outcomes gained through the study of both rare and common genetic variation. I also discuss whether recent testing of type 2 diabetes mellitus susceptibility loci in GDM case-control samples changes views of whether GDM is a distinct form of diabetes. Finally, I examine how the study of susceptibility loci can be used to influence clinical care, one of the great promises of the new era of human genome analysis.
尽管经过多年的研究，人们对妊娠糖尿病（GDM）的遗传易感性仍知之甚少。然而，全基因组关联分析和鉴定出与 2 型糖尿病易感性相关的基因座，为 GDM 的遗传学研究开辟了一个小窗口。更重要的是，对 GDM 遗传学的研究不仅阐明了妊娠糖尿病潜在的新生物学基础，而且还深入了解了胎儿结局。在这里，我通过研究罕见和常见的遗传变异，综述了一些关于 GDM 和胎儿结局的新见解。我还讨论了最近在 GDM 病例对照样本中检测 2 型糖尿病易感性基因座是否改变了 GDM 是否为一种独特的糖尿病形式的观点。最后，我研究了易感性基因座的研究如何用于影响临床护理，这是人类基因组分析新时代的一个巨大承诺。
Zotero 插件