Department of Emergency Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Crit Care. 2011 Mar 21;15(2):135. doi: 10.1186/cc10044.
The study by Yang and colleagues examined 81 patients with septic shock due to pneumonia, along with 20 patients with pneumonia without organ dysfunction. Their major findings were that circulating levels of soluble vascular endothelial cell growth factor receptor-1 (sVEGFR-1) and urokinase-type plasminogen activator (uPA) were associated with organ dysfunction and mortality, whereas vascular endothelial cell growth factor (VEGF) levels had no such predictive power. Yang and colleagues are to be complimented for a well-conducted study of a reasonably (and helpfully!) homogeneous population of patients with sepsis that carefully and comprehensively analyzed the relationship between sVEGFR-1, uPA, VEGF and clinical outcome. The study serves not only to provide evidence in support of new diagnostic biomarker targets in sepsis, but also to augment the growing evidence of an important role of the endothelium in sepsis in general, and the VEGF signaling axis in particular.
这项由杨及其同事进行的研究调查了 81 例因肺炎导致感染性休克的患者，以及 20 例无器官功能障碍的肺炎患者。他们的主要发现是，循环中可溶性血管内皮细胞生长因子受体-1（sVEGFR-1）和尿激酶型纤溶酶原激活物（uPA）的水平与器官功能障碍和死亡率相关，而血管内皮细胞生长因子（VEGF）水平则没有这种预测能力。杨及其同事进行了一项精心设计的研究，涉及一组相当（并且非常有用！）同质的败血症患者，他们仔细全面地分析了 sVEGFR-1、uPA、VEGF 与临床结局之间的关系，值得称赞。该研究不仅为败血症的新诊断生物标志物靶标提供了证据支持，而且还增加了越来越多的证据表明内皮细胞在败血症中具有重要作用，特别是 VEGF 信号通路。
