Osteoarthritis-osteoporosis Research Laboratory, Rheumatology Department, LaRabta Hospital, 1007 Tunis, Tunisia.
Arthritis Res Ther. 2011 Mar 18;13(2):208. doi: 10.1186/ar3255.
Osteoarthritis is the most prevalent form of arthritis in the world. With the progressive ageing of the population, it is becoming a major public health problem. The involvement of certain signaling pathways, such as the Notch pathway, during cartilage pathology has been reported. In this review, we report on studies that investigated the expression pattern of the Notch family members in articular cartilage and the eventual involvement of this pathway in the modulation of the physiology and pathology of chondrocytes. Temporal and/or spatial modulation of this signaling pathway may help these cells to synthesize a new functional extracellular matrix and restore the functional properties of the articular cartilage.
骨关节炎是世界上最普遍的关节炎形式。随着人口的逐渐老龄化，它正成为一个主要的公共卫生问题。已经有报道称，某些信号通路，如 Notch 通路，在软骨病变中起作用。在这篇综述中，我们报告了研究 Notch 家族成员在关节软骨中的表达模式以及该通路在调节软骨细胞生理和病理过程中的潜在作用的研究。对该信号通路进行时间和/或空间调节可能有助于这些细胞合成新的功能性细胞外基质并恢复关节软骨的功能特性。
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