Fazio Antonietta, Di Martino Alberto, Brunello Matteo, Traina Francesco, Marvi Maria Vittoria, Mazzotti Antonio, Faldini Cesare, Manzoli Lucia, Evangelisti Camilla, Ratti Stefano
Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126, Bologna, Italy.
Ist Orthopedic Department, IRCCS Istituto Ortopedico Rizzoli, 40136, Bologna, Italy.
J Orthop Translat. 2024 Jun 22;47:116-124. doi: 10.1016/j.jot.2024.06.002. eCollection 2024 Jul.
Osteoarthritis (OA) is one of the most common disabling pathologies, characterized by joint pain and reduced function, significantly worsening the quality of life. Even if important progresses have been made in OA research, little is yet known about the precise cellular and molecular mechanisms underlying OA. Understanding dysregulated signaling networks and their crosstalk in OA may offer a strong opportunity for the development of combined targeted therapies. Hence, this review highlights the recent findings on the main pathways involved in OA development, including Wnt, Notch, Hedgehog, MAPK, AMPK, and JAK/STAT, providing insights on current targeted therapies in OA patients' management.
The identification of key signaling pathways involved in OA development and the investigation of their signaling crosstalk could pave the way for more effective treatments and improved management of OA patients in the future.
骨关节炎（OA）是最常见的致残性疾病之一，其特征为关节疼痛和功能减退，严重恶化生活质量。尽管OA研究已取得重要进展，但对于OA潜在的精确细胞和分子机制仍知之甚少。了解OA中失调的信号网络及其相互作用可能为联合靶向治疗的开发提供有力契机。因此，本综述重点介绍了OA发展中主要通路的最新研究结果，包括Wnt、Notch、Hedgehog、MAPK、AMPK和JAK/STAT，为OA患者管理中的当前靶向治疗提供见解。
确定参与OA发展的关键信号通路并研究其信号相互作用可为未来更有效治疗OA患者和改善管理铺平道路。
