Braat S H, de Swart H, Janssen J H, Brugada P, Rigo P, Wellens H J
Department of Cardiology, Academic Hospital Maastricht, The Netherlands.
Am J Cardiol. 1990 Oct 16;66(13):85E-90E. doi: 10.1016/0002-9149(90)90618-b.
The value of the new radionuclide tracer, technetium-99m (Tc-99m) sestamibi, to demonstrate myocardial perfusion in areas supplied by specific coronary arteries was evaluated in patients injected with the agent during cardiac catheterization. Tc-99m sestamibi differs from thallium-201 in its physical characteristics (photon energy 140 keV), half-life (6 hours) and lack of significant redistribution, allowing its administration during an episode of chest pain or ischemia occurring outside the nuclear medicine laboratory with later imaging to visualize the distribution. In 13 patients Tc-99m sestamibi was administered intravenously during balloon-occlusion angioplasty. In 11 of 13 patients, defects of the single photon emission computed tomography images corresponded to the area made ischemic during angioplasty. In the remaining 2 patients, abundant collateral flow was present and no defects were seen. In a second study, 15 patients had Tc-99m sestamibi selectively injected into a coronary artery during angiography. Later imaging identified the area supplied by the artery injected. Tc-99m sestamibi imaging can detect perfusion defects associated with short episodes of ischemia, and the area supplied by the different coronary arteries.
在心脏导管插入术期间给患者注射新的放射性核素示踪剂锝-99m（Tc-99m）甲氧基异丁基异腈，以评估其在特定冠状动脉供血区域显示心肌灌注的价值。Tc-99m甲氧基异丁基异腈在物理特性（光子能量140keV）、半衰期（6小时）以及缺乏明显的再分布方面与铊-201不同，这使得它能够在核医学实验室之外发生胸痛或缺血发作期间给药，随后进行成像以观察其分布情况。在13例患者中，在球囊阻塞血管成形术期间静脉注射Tc-99m甲氧基异丁基异腈。13例患者中有11例，单光子发射计算机断层扫描图像上的缺损与血管成形术期间造成缺血的区域相对应。其余2例患者存在丰富的侧支血流，未见缺损。在第二项研究中，15例患者在血管造影期间将Tc-99m甲氧基异丁基异腈选择性地注入冠状动脉。随后的成像确定了注入动脉供血的区域。Tc-99m甲氧基异丁基异腈成像能够检测与短暂缺血发作相关的灌注缺损以及不同冠状动脉供血的区域。
