Department of Chemistry and the Richard E Smalley Institute for Nanoscale Science and Technology, Rice University, Houston, TX 77005, USA.
Breast Cancer Res. 2011 Mar 15;13(2):303. doi: 10.1186/bcr2830.
A recent study published in Nano Letters documents the synthesis and performance of porous silica nanocapsules filled with magnetic nanoparticles as a controllable magnetic drug delivery vector. Under a remotely applied radiofrequency magnetic field, these nanocapsules demonstrate on-off switchable release of the internally loaded drug payload. Both in vitro and in vivo studies using MT2 mouse breast cancer cell models demonstrate that the magnetic targeting of these nanocapsules allows for deep tumor penetration and subsequent on-demand release of the drug cargo, significantly reducing tumor cell viability.
最近发表在《纳诺快报》上的一项研究记录了多孔硅纳米胶囊的合成和性能，这些胶囊内填充了磁性纳米颗粒，可用作可控的磁性药物输送载体。在远程施加的射频磁场作用下，这些纳米胶囊能够实现内部负载药物的开关式释放。使用 MT2 小鼠乳腺癌细胞模型进行的体外和体内研究均表明，这些纳米胶囊的磁性靶向作用可实现肿瘤的深层穿透，随后按需释放药物有效成分，从而显著降低肿瘤细胞的活力。
