巴基斯坦开伯尔-普赫图赫瓦省和联邦直辖部落地区献血者中丙型肝炎病毒活跃感染的流行情况及抗 HCV 筛查试验的评估。
Prevalence of active HCV infection among the blood donors of Khyber Pakhtunkwa and FATA region of Pakistan and evaluation of the screening tests for anti-HCV.
机构信息
Institute of Biotechnology and Genetic Engineering, KPK Agricultural University, Peshawar, Pakistan.
出版信息
Virol J. 2011 Apr 1;8:154. doi: 10.1186/1743-422X-8-154.
Abstract
Hepatitis C is a fatal liver disease caused by the hepatitis C virus. In this study, blood donors, from various districts of the KPK province and the federally administered tribal area (FATA) of Pakistan were tested for anti-HCV antibodies and HCV RNA by ICT (Immuno-chromatographic test), ELISA and RT-PCR. Out of the 7148 blood donors, 224 (3.13%) were positive for anti-HCV antibodies by ICT, 135 (1.89%) by ELISA while 118 (1.65%) blood donors had active HCV infection as detected by RT-PCR. We suggest that ELISA should be used for anti-HCV screening in public sector hospitals and health care units.
摘要
丙型肝炎是一种由丙型肝炎病毒引起的致命肝脏疾病。在这项研究中，来自巴基斯坦开伯尔-普赫图赫瓦省和联邦直辖部落地区（FATA）不同地区的献血者通过 ICT（免疫层析试验）、ELISA 和 RT-PCR 检测抗 HCV 抗体和 HCV RNA。在 7148 名献血者中，224 名（3.13%）通过 ICT、135 名（1.89%）通过 ELISA 检测抗 HCV 抗体阳性，118 名（1.65%）献血者通过 RT-PCR 检测到 HCV 感染呈阳性。我们建议在公立医院和医疗机构使用 ELISA 进行抗 HCV 筛查。
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