Department of Psychiatry, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Schizophr Res. 2011 Jun;129(1):47-51. doi: 10.1016/j.schres.2011.03.013. Epub 2011 Apr 1.
Infections have been suggested to play a role in the etiology of schizophrenia, but the evidence for this has been inconsistent. Schizophrenia patients have an increased risk of infections as a result of hospitalizations or life style factors. Therefore a study on early subclinical manifestations of psychosis in relation to virus infections is warranted. We examined whether serum antibodies against human Herpes viruses and Toxoplasma gondii were associated with subclinical symptoms of psychosis in adolescents. Data were collected as part of the TRacking Adolescents' Individual Lives Survey (TRAILS) cohort, a large prospective cohort of Dutch adolescents. A total of 1176 participants with an available Community Assessment of Psychic Experiences (CAPE) and an available blood sample were included in this analysis. Solid-enzyme immunoassay methods were used to measure the presence of immunoglobulin G (IgG) antibodies in serum to the Herpes virus family and to T. gondii. There was no significant association between serologic evidence of infection with human Herpes viruses or T. gondii and the risk of subclinical positive experience of psychosis. Subjects with a positive serological reaction to Epstein-Barr Virus (EBV) had higher scores on the positive dimension of psychosis measured by CAPE (b=0.03, P=0.02). This significant association was observed in males, but not in females. The current study suggests that there is no significant association between serological evidence of infection to human Herpes viruses and positive subclinical experience of psychosis, whereas there was an association between EBV infection and subclinical psychotic symptoms in boys.
已有研究提示，感染可能在精神分裂症的发病机制中发挥作用，但相关证据一直存在争议。由于住院或生活方式等因素，精神分裂症患者感染的风险增加。因此，有必要研究病毒感染与精神病早期亚临床症状之间的关系。我们研究了青少年人群中，针对人类疱疹病毒和弓形虫的血清抗体是否与精神病亚临床症状相关。该研究数据来自于青少年个体生活轨迹（TRAILS）队列研究，这是一项针对荷兰青少年的大型前瞻性队列研究。本分析共纳入 1176 名参与者，他们均完成了社区心理体验评估（CAPE）和血样采集。采用固相酶免疫法检测血清中针对疱疹病毒家族和弓形虫的 IgG 抗体。感染人类疱疹病毒或弓形虫的血清学证据与亚临床阳性精神病体验风险之间无显著相关性。与 EBV 感染相关的阳性血清学反应的患者，其 CAPE 阳性维度评分更高（b=0.03，P=0.02）。这一显著相关性仅见于男性，而女性中未见。本研究提示，感染人类疱疹病毒的血清学证据与精神病亚临床阳性体验之间无显著相关性，而 EBV 感染与男孩的亚临床精神病症状之间存在相关性。
