Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA.
J Cyst Fibros. 2011 Jul;10(4):258-64. doi: 10.1016/j.jcf.2011.03.005. Epub 2011 Mar 31.
This study examined the relationship of medication adherence to frequency of pulmonary exacerbation and rate of decline in FEV(1)% predicted (FEV(1)).
95 CF patients aged 6 years or older and prescribed a pulmonary medication, were enrolled in a longitudinal retrospective review of medication adherence and health outcomes (the occurrence and frequency of intravenous (IV) antibiotic treatments and FEV(1)) over 12-months. Pharmacy refill records were used to calculate a medication possession ratio (MPR).
Composite MPR predicted the occurrence of at least one pulmonary exacerbation requiring a course of IV antibiotics (IRR=2.34, p=0.05), but not the frequency of exacerbations, after controlling for gender, baseline FEV(1,) and regimen complexity. Composite MPR predicted baseline FEV(1) (estimate=29.81, p=.007), but not decline in FEV(1).
These results demonstrate a significant relation between medication adherence and IV antibiotics in CF patients, highlighting the importance of addressing adherence during clinic visits to improve health outcomes.
本研究旨在探讨药物依从性与肺部恶化频率和 FEV(1)%预计值（FEV(1)）下降率之间的关系。
95 名年龄在 6 岁及以上且接受肺部药物治疗的 CF 患者，参与了一项关于药物依从性和健康结果（静脉（IV）抗生素治疗的发生和频率以及 FEV(1)）的 12 个月纵向回顾性研究。使用药房补充记录来计算药物持有率（MPR）。
复合 MPR 可预测至少一次需要 IV 抗生素治疗的肺部恶化（IRR=2.34，p=0.05），但在控制性别、基线 FEV(1)和方案复杂性后，不能预测恶化的频率。复合 MPR 可预测基线 FEV(1)（估计值=29.81，p=.007），但不能预测 FEV(1)的下降。
这些结果表明 CF 患者的药物依从性与 IV 抗生素之间存在显著关系，强调了在就诊期间解决依从性问题以改善健康结果的重要性。
