神经肽信号介导的突触前易化介导气味驱动的食物搜索。
Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search.
机构信息
Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Cell. 2011 Apr 1;145(1):133-44. doi: 10.1016/j.cell.2011.02.008.
Abstract
Internal physiological states influence behavioral decisions. We have investigated the underlying cellular and molecular mechanisms at the first olfactory synapse for starvation modulation of food-search behavior in Drosophila. We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to modulate olfactory sensitivity. Results from two-photon calcium imaging show that starvation increases presynaptic activity via intraglomerular sNPF signaling. Expression of sNPF and its receptor (sNPFR1) in Or42b neurons is necessary for starvation-induced food-search behavior. Presynaptic facilitation in Or42b neurons is sufficient to mimic starvation-like behavior in fed flies. Furthermore, starvation elevates the transcription level of sNPFR1 but not that of sNPF, and insulin signaling suppresses sNPFR1 expression. Thus, starvation increases expression of sNPFR1 to change the odor map, resulting in more robust food-search behavior.
摘要
内部生理状态会影响行为决策。我们研究了果蝇中第一个嗅觉突触内的细胞和分子机制，以了解饥饿对食物搜索行为的调节作用。我们发现，短神经肽 F（sNPF）的局部信号和胰岛素的全局代谢信号在特定的气味受体神经元（ORNs）中整合，以调节嗅觉敏感性。双光子钙成像的结果表明，饥饿通过神经肽 F 信号增加了突触前活动。在 Or42b 神经元中表达 sNPF 和其受体（sNPFR1）对于饥饿诱导的觅食行为是必需的。Or42b 神经元中的突触前易化足以模拟饱食果蝇的饥饿样行为。此外，饥饿会提高 sNPFR1 的转录水平，但不会提高 sNPF 的转录水平，而胰岛素信号会抑制 sNPFR1 的表达。因此，饥饿会增加 sNPFR1 的表达，从而改变气味图谱，导致更强烈的觅食行为。
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