卵圆孔未闭伴或不伴隐源性卒中患者的微栓子信号。
Microembolic signals in patients with cryptogenic stroke with or without patent foramen ovale.
机构信息
Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
J Stroke Cerebrovasc Dis. 2012 Nov;21(8):662-6. doi: 10.1016/j.jstrokecerebrovasdis.2011.02.015. Epub 2011 Apr 3.
BACKGROUND
To evaluate the incidence, frequency, and contributing factors of microembolic signals (MESs) in patients with cryptogenic stroke with or without patent foramen ovale (PFO).
METHODS
Transcranial Doppler monitoring for MESs detection was performed for 62 patients with acute cryptogenic stroke with PFO (PFO(+)) and 34 patients with acute cryptogenic stroke without PFO (PFO(-)).
RESULTS
The incidence of MESs was not significantly higher in PFO(+) patients (17/62, 27.4%) in comparison to PFO(-) patients (6/34, 17.6%; odds ratio 1.76, 95% confidence interval 0.62-5.00; P = .327). The frequency of MESs in PFO(+) patients was statistically higher than that of PFO(-) patients (0.70 ± 1.47 v 0.23 ± 0.55; P = .026). MESs was presented with higher incidence in a subgroup of patients suffering from both patent foramen ovale and atrial septal aneurysm (P = .044).
CONCLUSIONS
The likelihood of PFO as a source of MESs is higher when associated with atrial septal aneurysm.
背景
评估伴有或不伴有卵圆孔未闭（PFO）的隐源性卒中患者微栓子信号（MESs）的发生率、频率和相关因素。
方法
对 62 例伴有 PFO 的急性隐源性卒中患者（PFO（+））和 34 例不伴有 PFO 的急性隐源性卒中患者（PFO（-））进行经颅多普勒监测以检测 MESs。
结果
与 PFO（-）患者（6/34，17.6%；比值比 1.76，95%置信区间 0.62-5.00；P =.327）相比，PFO（+）患者的 MESs 发生率无显著升高（17/62，27.4%）。PFO（+）患者的 MESs 频率明显高于 PFO（-）患者（0.70±1.47 比 0.23±0.55；P =.026）。当 PFO 与房间隔瘤同时存在时，MESs 的发生率更高（P =.044）。
结论
当与房间隔瘤相关时，PFO 作为 MESs 来源的可能性更高。
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