内脏利什曼病的典型患者是谁?巴西、东非和南亚患者的人口统计学和营养状况特征。

Who is a typical patient with visceral leishmaniasis? Characterizing the demographic and nutritional profile of patients in Brazil, East Africa, and South Asia.

机构信息

Population Studies Center, University of Pennsylvania, Philadelphia, PA. USA.

出版信息

Am J Trop Med Hyg. 2011 Apr;84(4):543-50. doi: 10.4269/ajtmh.2011.10-0321.

Abstract

Drug-dosing recommendations for visceral leishmaniasis (VL) treatment are based on the patients' weight or age. A current lack of demographic and anthropometric data on patients hinders (1) the ability of health providers to properly prepare for patient management, (2) an informed drug procurement for disease control, and (3) the design of clinical trials and development of new drug therapies in the different endemic areas. We present information about the age, gender, weight, and height of 29,570 consecutive VL patients presenting to 20 locations in six geographic endemic regions of Brazil, East Africa, Nepal, and India between 1997 and 2009. Our compilation shows substantial heterogeneity in the types of patients seeking care for VL at the clinics within the different locations. This suggests that drug development, procurement, and perhaps even treatment protocols, such as the use of the potentially teratogenic drug miltefosine, may require distinct strategies in these geographic settings.

摘要

内脏利什曼病(VL)治疗的药物剂量推荐是基于患者的体重或年龄。目前,缺乏关于患者的人口统计学和人体测量学数据,这(1)阻碍了卫生保健提供者为患者管理做好充分准备的能力,(2)无法为疾病控制进行明智的药物采购,以及(3)在不同流行地区设计临床试验和开发新的药物治疗方法。我们提供了 1997 年至 2009 年间在巴西六个地理流行地区、东非、尼泊尔和印度的 20 个地点的 29570 例连续 VL 患者的年龄、性别、体重和身高信息。我们的汇编显示,在不同地点的诊所寻求 VL 治疗的患者类型存在很大的异质性。这表明药物开发、采购,甚至治疗方案,如使用潜在致畸药物米替福新,可能需要在这些地理环境中采取不同的策略。

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