Chen Tsung-Yen, Chen Jem-Kun
Department of Materials Science and Engineering, National Taiwan University of Science and Technology, 43, Sec 4, Keelung Rd, Taipei, 106 Taiwan Republic of China.
Colloid Polym Sci. 2011 Feb;289(4):433-445. doi: 10.1007/s00396-010-2370-z. Epub 2011 Jan 21.
In this paper, we describe a graft polymerization/solvent immersion method for generating poly(2-hydroxyethyl methacrylate) (PHEMA) brushes in various patterns. We used a novel fabrication process, involving very-large-scale integration and oxygen plasma treatment, to generate well-defined patterns of polymerized PHEMA on patterned Si(100) surfaces. We observed brush- and mushroom-like regions for the PHEMA brushes, with various pattern resolutions, after immersing wafers presenting lines of these polymers in MeOH and n-hexane, respectively. The interaction between PHEMA and ferritin protein sheaths in MeOH and n-hexane (good and poor solvent for PHEMA, respectively) was used to capture and release ferritins from fluidic system. The "tentacles" behaver for PHEMA brushes was found through various solvents in fluidic system. Using high-resolution scanning electron microscopy, we observed patterned ferritin Fe cores on the Si surface after pyrolysis of the patterned PHEMA brushes and ferritin protein sheaths, which verify the "tentacles" behaver for PHEMA brushes.
在本文中，我们描述了一种用于生成各种图案的聚甲基丙烯酸2-羟乙酯（PHEMA）刷的接枝聚合/溶剂浸渍方法。我们采用了一种新颖的制造工艺，包括超大规模集成电路和氧等离子体处理，以在图案化的Si(100)表面上生成定义明确的聚合PHEMA图案。在将呈现这些聚合物线条的晶片分别浸入甲醇和正己烷后，我们观察到了具有各种图案分辨率的PHEMA刷的刷状和蘑菇状区域。利用PHEMA与甲醇和正己烷（分别是PHEMA的良溶剂和不良溶剂）中乳铁蛋白蛋白鞘之间的相互作用，从流体系统中捕获和释放乳铁蛋白。通过流体系统中的各种溶剂发现了PHEMA刷的“触手”行为。使用高分辨率扫描电子显微镜，我们在图案化的PHEMA刷和乳铁蛋白蛋白鞘热解后观察到Si表面上图案化的乳铁蛋白铁核，这证实了PHEMA刷的“触手”行为。
