Basani Shailesh R, Ahmed Salwa Mohamed, Habte-Gabr Eyassu
Department of Internal Medicine, Hurley Medical Center, Flint, MI 48503, USA.
Case Rep Med. 2011;2011:916859. doi: 10.1155/2011/916859. Epub 2011 Mar 10.
Legionnaires' disease is primarily a pneumonic process caused by Legionella pneumophilia, a gram-negative aerobic bacillus but also has multiple system involvement. The most common manifestation is encephalopathy suggesting a generalized brain dysfunction but focal neurological manifestations have been reported. We report a patient with Legionella pneumonia associated with cerebellar dysfunction and unilateral facial nerve weakness. 51-year-old previously healthy male presented with shortness of breath, cough, slurred speech, and unsteadiness on feet associated with malaise, fevers and myalgias. Patient's family reported facial asymmetry for 2 days. Patient had no significant medical history and was not on any medication. He denied smoking, alcohol or illicit drug use. Chest X-ray showed bilateral lower lobe infiltrates. Urinary antigen assay for Legionella pneumophilia serogroup 1 was positive. Patient was started on intravenous moxifloxacin. On day 5 the patient was discharged home and continued oral moxifloxacin for two weeks. After the two weeks, his respiratory symptoms, gait ataxia and dysarthria resolved. We report the first case of Legionnaires' disease with cerebellar dysfunction and seventh nerve palsy. Legionnaires' disease should be considered in patients with any neurological symptoms in the setting of pneumonia. Failure to recognize and treat the infection may lead to poor outcomes.
军团病主要是由嗜肺军团菌引起的肺部感染过程,嗜肺军团菌是一种革兰氏阴性需氧杆菌,但也会累及多个系统。最常见的表现是脑病,提示存在广泛性脑功能障碍,但也有局灶性神经表现的报道。我们报告一例军团菌肺炎患者,伴有小脑功能障碍和单侧面神经麻痹。一名51岁既往健康男性,出现呼吸急促、咳嗽、言语不清、步态不稳,伴有全身不适、发热和肌痛。患者家属报告其面部不对称已有2天。患者无重大病史,未服用任何药物。他否认吸烟、饮酒或使用非法药物。胸部X线显示双侧下叶浸润。嗜肺军团菌血清型1的尿抗原检测呈阳性。患者开始静脉注射莫西沙星。第5天患者出院回家,继续口服莫西沙星两周。两周后,他的呼吸道症状、步态共济失调和构音障碍均得到缓解。我们报告了首例伴有小脑功能障碍和第七神经麻痹的军团病病例。对于肺炎患者出现任何神经症状时,都应考虑军团病。未能识别和治疗该感染可能导致不良后果。