Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Clin Exp Otorhinolaryngol. 2011 Mar;4(1):1-10. doi: 10.3342/ceo.2011.4.1.1. Epub 2011 Mar 17.
The oral cavity is the most common site of head and neck squamous cell carcinoma, a disease which results in significant morbidity and mortality worldwide. Though the primary modality of treatment for patients with oral cavity cancer remains surgical resection, many patients present with advanced disease and are thus treated using a multi-disciplinary approach. Patients with extracapsular spread of lymphatic metastasis and surgical margins that remain positive have been found to be at high risk for local-regional recurrence and death from disease, and are most often recommended to receive both post-operative radiation as well as systemic chemotherapy. The basis for this approach, as well as scientific developments that underly future trials of novels treatments for patients with high-risk oral cavity cancer are reviewed.
口腔是头颈部鳞状细胞癌最常见的部位，这种疾病在全球范围内导致了相当高的发病率和死亡率。尽管手术切除仍然是口腔癌患者的主要治疗方式，但许多患者已处于晚期疾病，因此需要采用多学科方法进行治疗。已经发现，患有淋巴转移包膜外扩散和手术切缘阳性的患者发生局部区域复发和疾病死亡的风险很高，通常建议他们接受术后放疗和全身化疗。本文回顾了这种治疗方法的依据，以及为高危口腔癌患者进行新型治疗方法试验提供依据的科学进展。
