静止性炎症性肠病与周围性多发性神经病的关系。
The Relationship between Quiescent Inflammatory Bowel Disease and Peripheral Polyneuropathy.
机构信息
Department of Gastroenterology, Kocaeli Derince Research and Education Hospital, Kocaeli, Turkey.
出版信息
Gut Liver. 2011 Mar;5(1):57-60. doi: 10.5009/gnl.2011.5.1.57. Epub 2011 Mar 16.
BACKGROUND/AIMS: Inflammatory bowel disease is a chronic, recurrent disorder that involves multiple organ systems. Polyneuropathy is the most common neurological manifestation. The aim of the present study was to investigate the relationship between polyneuropathy and inflammatory bowel disease.
METHODS
The study included 40 patients with infl ammatory bowel disease (20 with ulcerative colitis and 20 with Crohn's disease) and 24 healthy controls. The patients had no clinical signs or symptoms of polyneuropathy. Nerve conduction studies were performed using an electroneuromyography apparatus.
RESULTS
Mean distal motor latencies, conduction velocities, and F wave minimum latencies of the right median nerve were signifi cantly abnormal in the patient group, compared to the healthy controls (p<0.05).
CONCLUSIONS
Some electrophysiological alterations were observed in chronic inflammatory bowel disease patients who showed no clinical signs. While investigating extra-intestinal manifestations in inflammatory bowel disease patients, nerve conduction studies must be performed to identify electrophysiological changes and subclinical peripheral polyneuropathy, which can subsequently develop.
背景/目的：炎症性肠病是一种涉及多个器官系统的慢性、复发性疾病。多发性神经病是最常见的神经表现。本研究旨在探讨多发性神经病与炎症性肠病之间的关系。
方法
本研究纳入了 40 例炎症性肠病患者（溃疡性结肠炎 20 例，克罗恩病 20 例）和 24 名健康对照者。这些患者没有多发性神经病的临床症状或体征。使用肌电图仪进行神经传导研究。
结果
与健康对照组相比，患者组右侧正中神经的远端运动潜伏期、传导速度和 F 波最小潜伏期均明显异常（p<0.05）。
结论
在无临床症状的慢性炎症性肠病患者中观察到一些电生理改变。在炎症性肠病患者中检查肠外表现时，必须进行神经传导研究以识别电生理变化和亚临床周围多发性神经病，随后可能会发展为多发性神经病。
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