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设拉子：一种用于斑马鱼表型组学的自动化组织学图像注释系统。

SHIRAZ: an automated histology image annotation system for zebrafish phenomics.

作者信息

Canada Brian A, Thomas Georgia K, Cheng Keith C, Wang James Z

出版信息

Multimed Tools Appl. 2011 Jan;51(2):401-440. doi: 10.1007/s11042-010-0638-4. Epub 2010 Oct 24.

DOI:10.1007/s11042-010-0638-4
PMID:21461317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3066164/
Abstract

Histological characterization is used in clinical and research contexts as a highly sensitive method for detecting the morphological features of disease and abnormal gene function. Histology has recently been accepted as a phenotyping method for the forthcoming Zebrafish Phenome Project, a large-scale community effort to characterize the morphological, physiological, and behavioral phenotypes resulting from the mutations in all known genes in the zebrafish genome. In support of this project, we present a novel content-based image retrieval system for the automated annotation of images containing histological abnormalities in the developing eye of the larval zebrafish.

摘要

组织学特征在临床和研究环境中被用作一种高度敏感的方法，用于检测疾病的形态特征和异常基因功能。组织学最近已被接受作为即将开展的斑马鱼表型组计划的一种表型分析方法，这是一项大规模的社区努力，旨在表征斑马鱼基因组中所有已知基因突变所导致的形态、生理和行为表型。为支持该项目，我们提出了一种基于内容的新型图像检索系统，用于自动注释斑马鱼幼体发育眼睛中包含组织学异常的图像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/d54dbd5ec4da/11042_2010_638_Fig19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/71e44dc3eea1/11042_2010_638_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/abe58b2acb36/11042_2010_638_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/9a917921a172/11042_2010_638_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/3b515b1fa982/11042_2010_638_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/8c969195ec91/11042_2010_638_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/58c00c948f3a/11042_2010_638_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/df64abd253ce/11042_2010_638_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/c3b94800809b/11042_2010_638_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/35e1e09b3ad7/11042_2010_638_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/84af29256428/11042_2010_638_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/edabfd0ab3f5/11042_2010_638_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/bba7c182b48a/11042_2010_638_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/9ff20327bc36/11042_2010_638_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/66574faff673/11042_2010_638_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/9ed0a0041e79/11042_2010_638_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/5c301cd22d9a/11042_2010_638_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/b2f96dd556a8/11042_2010_638_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/92f4fb1fc70a/11042_2010_638_Fig18_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/d54dbd5ec4da/11042_2010_638_Fig19_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/71e44dc3eea1/11042_2010_638_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/abe58b2acb36/11042_2010_638_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/9a917921a172/11042_2010_638_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/3b515b1fa982/11042_2010_638_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/8c969195ec91/11042_2010_638_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/58c00c948f3a/11042_2010_638_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/df64abd253ce/11042_2010_638_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/c3b94800809b/11042_2010_638_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/35e1e09b3ad7/11042_2010_638_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/84af29256428/11042_2010_638_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/edabfd0ab3f5/11042_2010_638_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/bba7c182b48a/11042_2010_638_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/9ff20327bc36/11042_2010_638_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/66574faff673/11042_2010_638_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/9ed0a0041e79/11042_2010_638_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/5c301cd22d9a/11042_2010_638_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/b2f96dd556a8/11042_2010_638_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/92f4fb1fc70a/11042_2010_638_Fig18_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f487/3066164/d54dbd5ec4da/11042_2010_638_Fig19_HTML.jpg

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