哈萨克斯坦分离的H11亚型禽流感病毒的系统发育分析。
Phylogenetic analysis of avian influenza viruses of H11 subtype isolated in Kazakhstan.
作者信息
Karamendin Kobey, Kydyrmanov Aidyn, Zhumatov Kainar, Asanova Saule, Ishmukhametova Naylya, Sayatov Marat
机构信息
Laboratory of Viral Ecology, Institute of Microbiology and Virology, 103 Bogenbay batyr st, Almaty, 050010, Kazakhstan.
出版信息
Virus Genes. 2011 Aug;43(1):46-54. doi: 10.1007/s11262-011-0603-y. Epub 2011 Apr 2.
Avian influenza viruses A/turkey/Almaty/535/04 (H11N9) and A/herring gull/Atyrau/2186/07 (H11N2) isolated in Kazakhstan were characterized as low pathogenic in biological and genetic studies. Putative glycosylation sites were identical to the putative sites in published H11, N2, and N9 isolates sequences. Compared with published data no additional basic amino acid residues were found in the hemagglutinin (HA) cleavage site of these Kazakhstan strains. Phylogenetic analysis revealed a rare case of Eurasian-American reassortment in the HA gene of A/herring gull/Atyrau/2186/07 (H11N2) virus and significant sequence difference of the HA and the neuraminidase genes of the virus A/turkey/Almaty/535/04 (H11N9) from the previously published GenBank viruses.
在哈萨克斯坦分离出的禽流感病毒A/火鸡/阿拉木图/535/04（H11N9）和A/银鸥/阿特劳/2186/07（H11N2）在生物学和遗传学研究中被鉴定为低致病性。推测的糖基化位点与已发表的H11、N2和N9分离株序列中的推测位点相同。与已发表的数据相比，在这些哈萨克斯坦毒株血凝素（HA）裂解位点未发现额外的碱性氨基酸残基。系统发育分析显示，A/银鸥/阿特劳/2186/07（H11N2）病毒的HA基因中出现了罕见的欧亚-美洲重配情况，且病毒A/火鸡/阿拉木图/535/04（H11N9）的HA和神经氨酸酶基因与之前发表在GenBank上的病毒存在显著序列差异。
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