关于药用植物及其生物活性成分抗禽流感的系统评价及通过分析进一步确认

A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through analysis.

作者信息

Dutta Ashit Kumar, Gazi Md Shamim, Uddin Shaikh Jamal

机构信息

Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.

Biotechnology and Genetic Engineering Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.

出版信息

Heliyon. 2023 Mar 10;9(3):e14386. doi: 10.1016/j.heliyon.2023.e14386. eCollection 2023 Mar.

DOI:10.1016/j.heliyon.2023.e14386

PMID:36925514

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10011005/

Abstract

BACKGROUND

Avian influenza or more commonly known as bird flu is a widespread infectious disease in poultry. This review aims to accumulate information of different natural plant sources that can aid in combating this disease. Influenza virus (IV) is known for its ability to mutate and infect different species (including humans) and cause fatal consequences.

METHODS

Total 33 plants and 4 natural compounds were identified and documented. Molecular docking was performed against the target viral protein neuraminidase (NA), with some plant based natural compounds and compared their results with standard drugs Oseltamivir and Zanamivir to obtain novel drug targets for influenza in chickens.

RESULTS

It was seen that most extracts exhibit their action by interacting with viral hemagglutinin or neuraminidase and inhibit viral entry or release from the host cell. Some plants also interacted with the viral RNA replication or by reducing proinflammatory cytokines. Ethanol was mostly used for extraction. Among all the plants exhibited their activity with least concentration (below 10 μg/ml). The dockings results showed that some natural compounds (5,7- dimethoxyflavone, Aloe emodin, Anthocyanins, Quercetin, Hemanthamine, Lyocrine, Terpenoid EA showed satisfactory binding affinity and binding specificity with viral neuraminidase compared to the synthetic drugs.

CONCLUSION

This review clusters up to date information of effective herbal plants to bolster future influenza treatment research in chickens. The in-silico analysis also suggests some potential targets for future drug development but these require more clinical analysis.

摘要

背景

禽流感，或更常见的称法为鸟流感，是家禽中一种广泛传播的传染病。本综述旨在收集不同天然植物来源的信息，这些信息有助于对抗这种疾病。流感病毒（IV）以其变异能力以及感染不同物种（包括人类）并导致致命后果而闻名。

方法

共鉴定并记录了33种植物和4种天然化合物。针对目标病毒蛋白神经氨酸酶（NA）进行了分子对接，使用了一些基于植物的天然化合物，并将其结果与标准药物奥司他韦和扎那米韦进行比较，以获得鸡流感的新型药物靶点。

结果

可以看出，大多数提取物通过与病毒血凝素或神经氨酸酶相互作用来发挥作用，抑制病毒进入或从宿主细胞中释放。一些植物还与病毒RNA复制相互作用或通过减少促炎细胞因子来发挥作用。乙醇大多用于提取。在所有植物中，[此处原文似乎不完整]以最低浓度（低于10μg/ml）表现出活性。对接结果表明，与合成药物相比，一些天然化合物（5,7 - 二甲氧基黄酮、芦荟大黄素、花青素、槲皮素、海芒果胺、石蒜碱、萜类EA）与病毒神经氨酸酶表现出令人满意的结合亲和力和结合特异性。