Caspase 8 和 caspase 9 基因多态性与胃癌易感性。
Caspase 8 and caspase 9 gene polymorphisms and susceptibility to gastric cancer.
机构信息
1st Surgical Department, Tzaneion Hospital, Piraeus, Greece.
出版信息
Gastric Cancer. 2011 Oct;14(4):317-21. doi: 10.1007/s10120-011-0045-1. Epub 2011 Apr 2.
BACKGROUND
Caspase-8 (CASP8) and caspase-9 (CASP9) play crucial roles in regulating apoptosis, and their functional polymorphisms may alter cancer risk. Our aim was to investigate the association of CASP8 and CASP9 gene polymorphisms with gastric cancer (GC) susceptibility.
METHODS
We undertook a case-control study of 88 GC cases and 480 controls to investigate the association between CASP8 -652 6N ins/del and CASP9 -1263 A>G polymorphisms and GC susceptibility by a polymerase chain reaction (PCR)-restriction fragment length polymorphism method.
RESULTS
CASP8 -652 6N ins/del polymorphism and CASP9 -1263 GG genotype were observed to be significantly associated with a reduced risk of GC. No significant association was observed between CASP8 -652 6N ins/del and CASP9 -1263 A>G polymorphisms and tumor characteristics. However, both CASP8 del/del and CASP9 -1263 GG genotypes were associated with increased overall survival in GC patients.
CONCLUSIONS
The CASP8 -652 6N ins/del and the CASP9 -1263 A>G polymorphisms were observed to play a protective role in GC predisposition.
背景
半胱氨酸天冬氨酸蛋白酶-8（CASP8）和半胱氨酸天冬氨酸蛋白酶-9（CASP9）在调节细胞凋亡中起着至关重要的作用，它们的功能多态性可能改变癌症风险。我们的目的是研究 CASP8 和 CASP9 基因多态性与胃癌（GC）易感性的关系。
方法
我们进行了一项病例对照研究，包括 88 例 GC 病例和 480 例对照，采用聚合酶链反应（PCR）-限制性片段长度多态性方法，研究 CASP8-652 6N ins/del 和 CASP9-1263 A>G 多态性与 GC 易感性之间的关系。
结果
CASP8-652 6N ins/del 多态性和 CASP9-1263 GG 基因型与 GC 风险降低显著相关。未观察到 CASP8-652 6N ins/del 与 CASP9-1263 A>G 多态性与肿瘤特征之间存在显著关联。然而，CASP8 del/del 和 CASP9-1263 GG 基因型均与 GC 患者的总生存时间增加相关。
结论
CASP8-652 6N ins/del 和 CASP9-1263 A>G 多态性在 GC 易感性中起保护作用。
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